Uncategorized

Cannabinoids for the treatment of autoimmune and inflammatory skin diseases: A systematic review

By March 27, 2024March 28th, 2024No Comments

Review
. 2024 Mar;33(3):e15064.

doi: 10.1111/exd.15064.

Ai Kuzumi 1, Takashi Yamashita 1, Takemichi Fukasawa 1 2, Asako Yoshizaki-Ogawa 1, Shinichi Sato 1, Ayumi Yoshizaki 1 2
Affiliations 

Abstract

In recent years, the medical use of cannabinoids has attracted growing attention worldwide. In particular, anti-inflammatory properties of cannabinoids led to their emergence as potential therapeutic options for autoimmune and inflammatory disorders. Recent studies have also shown that cannabinoid receptors are widely expressed and have endogenous ligands in the skin, suggesting that the skin has its own endocannabinoid system. The aim of this review is to discuss the potential therapeutic effects of cannabinoids in autoimmune and inflammatory skin diseases. Following an overview of cannabinoids and the endocannabinoid system, we describe the cellular and molecular mechanisms of cannabinoids in skin health and disease. We then review the clinical studies of cannabinoids in autoimmune and inflammatory skin diseases including systemic sclerosis (SSc), dermatomyositis (DM), psoriasis (Pso) and atopic dermatitis (AD). A primary literature search was conducted in July 2023, using PubMed and Web of Science. A total of 15 articles were included after excluding reviews, non-human studies and in vitro studies from 389 non-duplicated articles. Available evidence suggests that cannabinoids may be beneficial for SSc, DM, Pso and AD. However, further studies, ideally randomized controlled trials, are needed to further evaluate the use of cannabinoids in autoimmune and inflammatory skin diseases.

Keywords: atopic dermatitis, auto‐immune disease, psoriasis

PubMed Disclaimer

References

REFERENCES

    1. Lu HC, Mackie K. An introduction to the endogenous cannabinoid system. Biol Psychiatry. 2016;79(7):516‐525.
    1. Crocq MA. History of cannabis and the endocannabinoid system. Dialogues Clin Neurosci. 2020;22(3):223‐228.
    1. Mechoulam R, Shvo Y. Hashish. I. The structure of cannabidiol. Tetrahedron. 1963;19(12):2073‐2078.
    1. Mechoulam R, Gaoni Y. A total synthesis of dl‐DELTA‐1‐tetrahydrocannabinol, the active constituent of HASHISH. J Am Chem Soc. 1965;87:3273‐3275.
    1. Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 1990;346(6284):561‐564.

Publication types

MeSH terms

Substances

Leave a Reply