Two marihuana constituents, cannabidiol (1) and cannabidiolic acid (4) were each converted mainly to two metabolites using tissue segments of Pinellia ternata tuber. The structures of the metabolites formed from 1 were determined to be 1-Oβ-D-glucopyranoside and 1-Oβ-D-diglucopyranoside by (1)H nmr, (13)C nmr and fabms. Those from 4 were determined as 4-Oβ-D-glucopyranoside and 10′-hydroxyl 4-Oβ-D-glucopyranoside. In time course experiments, 1 was absorbed rapidly by the tissues and glucosylated. Hydroxylation subsequent to the glucosylation occurred at the pentyl group in 4.

PMID:

 

24178215

 

[PubMed – in process]