Canna~Fangled Abstracts

Cannabis use does not impact on type 2 diabetes: A two-sample Mendelian randomization study

By February 12, 2021February 15th, 2021No Comments
This study adds to the evidence base that cannabis use does not play a causal role in type 2 diabetes.
. 2021 Feb 12;e13020.

doi: 10.1111/adb.13020.

Online ahead of print.
Sebastian-Edgar Baumeister 1 2 3, Michael Nolde 1 2, Zoheir Alayash 1, Michael Leitzmann 4, Hansjörg Baurecht 4, Christa Meisinger 1 2
Affiliations 

Abstract

Cannabis has effects on the insulin/glucose metabolism. As the use of cannabis and the prevalence of type 2 diabetes increase worldwide, it is important to examine the effect of cannabis on the risk of diabetes. We conducted a Mendelian randomization (MR) study by using 19 single-nucleotide polymorphisms (SNPs) as instrumental variables for lifetime cannabis use and 14 SNPs to instrument cannabis use disorder and linking these to type 2 diabetes risk using genome-wide association study data (lifetime cannabis use [N = 184,765]; cannabis use disorder [2387 cases/48,985 controls], type 2 diabetes [74,124 cases/824,006 controls]). The MR analysis suggested no effect of lifetime cannabis use (inverse-variance weighted odds ratio [95% confidence interval] = 1.00 [0.93-1.09], P value = 0.935) and cannabis use disorder (OR = 1.03 [0.99-1.08]) on type 2 diabetes. Sensitivity analysis to assess potential pleiotropy led to no substantive change in the estimates. This study adds to the evidence base that cannabis use does not play a causal role in type 2 diabetes.

 

Keywords: cannabis, diabetes

References

REFERENCES

    1. Hall W, Lynskey M. Assessing the public health impacts of legalizing recreational cannabis use: the US experience. World Psychiatry. 2020;19(2):179-186.
    1. Cho NH, Shaw JE, Karuranga S, et al. IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271-281.
    1. Alshaarawy O, Anthony JC. Cannabis smoking and diabetes mellitus: results from meta-analysis with eight independent replication samples. Epidemiology. 2015;26(4):597-600.
    1. Pastor A, Conn J, MacIsaac RJ, Bonomo Y. Alcohol and illicit drug use in people with diabetes. Lancet Diabetes Endocrinol. 2020;8(3):239-248.
    1. Ravi D, Ghasemiesfe M, Korenstein D, Cascino T, Keyhani S. Associations between marijuana use and cardiovascular risk factors and outcomes: a systematic review. Ann Intern Med. 2018;168(3):187-194.

LinkOut – more resources

  • Full Text Sources

Leave a Reply