doi: 10.1007/978-3-030-57369-0_1.
- PMID: 33332000
- DOI: 10.1007/978-3-030-57369-0_1
Abstract
The Cannabis sativa plant has been used medicinally and recreationally for thousands of years, but recently only relatively some of its constituents have been identified. There are more than 550 chemical compounds in cannabis, with more than 100 phytocannabinoids being identified, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). These phytocannabinoids work by binding to the cannabinoid receptors, as well as other receptor systems. Also within cannabis are the aromatic terpenes, more than 100 of which have been identified. Cannabis and its constituents have been indicated as therapeutic compounds in numerous medical conditions, such as pain, anxiety, epilepsy, nausea and vomiting, and post-traumatic stress disorder. This chapter provides an overview of some of the biological effects of a number of the cannabinoids and terpenes, as well as discussing their known mechanisms of action and evidence of potential therapeutic effects.
Keywords: Cannabidiol, Cannabinoid receptors, Cannabis sativa, Phytocannabinoid, Terpene, Δ9-tetrahydrocannabinol
References
-
- Abrams DI, Couey P, Shade SB et al (2011) Cannabinoid-opioid interaction in chronic pain. Clin Pharmacol Ther 90:844–851. https://doi.org/10.1038/clpt.2011.188 – DOI – PubMed – PMC
-
- Adams R, Hunt M, Clark JH (1940) Structure of cannabidiol, a product isolated from the marihuana extract of Minnesota wild hemp. I. J Am Chem Soc 62:196–200. https://doi.org/10.1021/ja01858a058 – DOI
-
- Ahmed SA, Ross SA, Slade D et al (2008) Cannabinoid ester constituents from high-potency Cannabis sativa. J Nat Prod 71:536–542. https://doi.org/10.1021/np070454a – DOI – PubMed – PMC
-
- Ahmed SA, Ross SA, Slade D et al (2015) Minor oxygenated cannabinoids from high potency Cannabis sativa. Phytochemistry 117:194–199. https://doi.org/10.1016/j.phytochem.2015.04.007 – DOI – PubMed – PMC
