Canna~Fangled Abstracts

Effect of oral cannabis administration on the fat depots of obese and streptozotocin-induced diabetic rats

By November 27, 2022November 29th, 2022No Comments


doi: 10.1002/ptr.7694.

Online ahead of print.
Affiliations 

Abstract

The prevalence of obesity and insulin-resistance is on the rise, globally. Cannabis have been shown to have anti-diabetic/obesity properties, however, the effect mediated at various fat depots remains to be clarified. The aim of this study was to (1) investigate the anti-diabetic property of an oral cannabis administration in an obese and streptozotocin-induced diabetic rat model and (2) to determine and compare the effect mediated at the peritoneal and intramuscular fat level. Cannabis concentration of 1.25 mg/kg body weight (relative to THC content) was effective in reversing insulin-resistance in the rat model, unlike the other higher cannabinoid concentrations. At the peritoneal fat level, gene expression of fat beigeing markers, namely Cidea and UCP1, were significantly increased compared to the untreated control. At the intramuscular fat level, on the other hand, CE1.25 treatment did not promote fat beigeing but instead significantly increased mitochondrial activity, relative to the untreated control. Therefore, these findings indicate that the mechanism of action of oral cannabis administration, where glucose and lipid homeostasis is restored, is not only dependent on the dosage but also on the type of fat depot investigated.

Keywords: UCP1, beigeing, cannabis, intramuscular, mitochondria, peritoneal

References

REFERENCES

    1. Abreu-Vieira, G., Fischer, A. W., Mattsson, C., de Jong, J. M. A., Shabalina, I. G., Rydén, M., … Petrovic, N. (2015). Cidea improves the metabolic profile through expansion of adipose tissue. Nature Communications, 6, 1-16. https://doi.org/10.1038/ncomms8433
    1. Ahmad, M. N., & Zawatia, A. A. (2021). Current prospects of metabolically healthy obesity. Obesity Medicine, 25, 100361. https://doi.org/10.1016/j.obmed.2021.100361
    1. Ahmed, B., Sultana, R., & Greene, M. W. (2021). Adipose tissue and insulin resistance in obese. Biomedicine and Pharmacotherapy, 137, 111315. https://doi.org/10.1016/j.biopha.2021.111315
    1. Al Shoyaib, A., Archie, S. R., & Karamyan, V. T. (2020). Intraperitoneal route of drug administration: should it be used in experimental animal studies? Pharmaceutical Research, 37(1), 1-17. https://doi.org/10.1007/s11095-019-2745-x
    1. Arhire, L. I., Mihalache, L., & Covasa, M. (2019). Irisin: A hope in understanding and managing obesity and metabolic syndrome. Frontiers in Endocrinology, 10, 1-12. https://doi.org/10.3389/fendo.2019.00524

Leave a Reply