Effects of cannabidiol (CBD) on the inhibition of melanoma cells in vitro

doi: 10.1080/15321819.2020.1862863.

Online ahead of print.

Rosemary Burch¹, Asif Mortuza¹, Elliott Blumenthal¹, Ahmed Mustafa¹

Affiliations

PMID: 33428525
DOI: 10.1080/15321819.2020.1862863

Abstract

Cannabidiol (CBD) is one of the most popular emerging plant extracts that is being investigated for its wide range of potential health benefits. This experiment tests how B16 mice melanoma cells, are affected by four different concentrations (0.2 mg/mL, 0.04 mg/mL, 0.008 mg/mL and 0.0016 mg/mL) of 99% CBD oil. The results of this experiment demonstrate that CBD significantly inhibited melanoma cell growth in-vitro at 0.2 mg/mL and 0.04 mg/mL. This shows that CBD has the potential to inhibit melanoma cell growth in vertebrates, namely mice.

Keywords: in vitro, CBD, Cannabidiol, melanoma, mice, spleen T cells, spleen cells

Similar articles

Quality Traits of “Cannabidiol Oils”: Cannabinoids Content, Terpene Fingerprint and Oxidation Stability of European Commercially Available Preparations.

Pavlovic R, Nenna G, Calvi L, Panseri S, Borgonovo G, Giupponi L, Cannazza G, Giorgi A.Molecules. 2018 May 20;23(5):1230. doi: 10.3390/molecules23051230.PMID: 29783790 Free PMC article.
Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells.

Kozela E, Juknat A, Gao F, Kaushansky N, Coppola G, Vogel Z.J Neuroinflammation. 2016 Jun 3;13(1):136. doi: 10.1186/s12974-016-0603-x.PMID: 27256343 Free PMC article.
Cannabidiol-from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer.

Kis B, Ifrim FC, Buda V, Avram S, Pavel IZ, Antal D, Paunescu V, Dehelean CA, Ardelean F, Diaconeasa Z, Soica C, Danciu C.Int J Mol Sci. 2019 Nov 25;20(23):5905. doi: 10.3390/ijms20235905.PMID: 31775230 Free PMC article. Review.
DMH-CBD, a cannabidiol analog with reduced cytotoxicity, inhibits TNF production by targeting NF-kB activity dependent on A_2A receptor.

Silva RL, Silveira GT, Wanderlei CW, Cecilio NT, Maganin AGM, Franchin M, Marques LMM, Lopes NP, Crippa JA, Guimarães FS, Alves-Filho JCF, Cunha FQ, Cunha TM.Toxicol Appl Pharmacol. 2019 Apr 1;368:63-71. doi: 10.1016/j.taap.2019.02.011. Epub 2019 Feb 20.PMID: 30796934
Lack of evidence for the effectiveness or safety of over-the-counter cannabidiol products.

Chesney E, McGuire P, Freeman TP, Strang J, Englund A.Ther Adv Psychopharmacol. 2020 Sep 9;10:2045125320954992. doi: 10.1177/2045125320954992. eCollection 2020.PMID: 32973998 Free PMC article. Review.

See all similar articles

Effects of cannabidiol (CBD) on the inhibition of melanoma cells in vitro

Abstract

Similar articles

Freedom Wares

Previous PostCannabidiol for the Treatment of Neonatal Hypoxic-Ischemic Brain Injury

Next PostEndocannabinoids and cortical plasticity: CB1R as a possible regulator of the excitation/inhibition balance in health and disease

Leave a Reply Cancel Reply