A review. Up-to-date concepts of endocannabinoid signalling in central nervous system of vertebrates are summarized. An overview of receptor-mediated mechanisms of synaptic transmission modulation by endocannabinoids in the brain and possibilities of direct effects of some cannabinoids on voltage-gated ion channels and neuronal activity is given. In the second part of the article, studies of endocannabinoid system in different phyla of invertebrate animals, from hydra to sea urchin, are analyzed in detail.

PMID:

 

23227725

 

[PubMed – indexed for MEDLINE]