Canna~Fangled Abstracts

GC-MS Metabolite Profile and Identification of Unusual Homologous Cannabinoids in High Potency Cannabis sativa.

By February 13, 2020 February 14th, 2020 No Comments
2020 Feb 13. doi: 10.1055/a-1110-1045.
[Epub ahead of print]


Phytochemical investigation of the lipids extracted from seeds of Cannabis sativa by GC-MS showed 43 cannabinoids, 16 of which are new. The extract is dominated by Δ9-tetrahydrocannabinolic acid (A) and its neutral derivative trans9-tetrahydrocannabinol-C5 (THC) Cis and trans9-tetrahydrocannabinol-C7 isomers with an ethyl-pentyl branched chain together with minor amounts of trans9-tetrahydrocannabinol with a methyl-pentyl Cbranched side chain were identified as new natural compounds. Four cannabichromene isomers with a C5 side chain are postulated to be derived from the double bond migration at the terminal isoprenyl unit. Ccannabichromene together with the neutral and acidic forms of cannabinol-C7 were also detected. The mass spectrum of these homologues as trimethylsilyl (TMS) derivatives are presented, and the fragmentation patterns are discussed.

PMID: 32053835
DOI: 10.1055/a-1110-1045

Conflict of interest statement

The authors declare that they have no conflict of interest.

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