Canna~Fangled Abstracts

Innovative treatments for epilepsy: Venom peptides, cannabinoids, and neurostimulation

By August 7, 2022August 8th, 2022No Comments


doi: 10.1002/jnr.25114.

Online ahead of print.


Antiepileptic drugs have been successfully treating epilepsy and providing individuals sustained seizure freedom. However, about 30% of the patients with epilepsy present drug resistance, which means they are not responsive to the pharmacological treatment. Considering this, it becomes extremely relevant to pursue alternative therapeutic approaches, in order to provide appropriate treatment for those patients and also improve their quality of life. In the light of that, this review aims to discuss some innovative options for the treatment of epilepsy, which are currently under investigation, addressing strategies that go from therapeutic compounds to clinical procedures. For instance, peptides derived from animal venoms, such as wasps, spiders, and scorpions, demonstrate to be promising antiepileptic molecules, acting on a variety of targets. Other options are cannabinoids and compounds that modulate the endocannabinoid system, since it is now known that this network is involved in the pathophysiology of epilepsy. Furthermore, neurostimulation is another strategy, being an alternative clinical procedure for drug-resistant patients who are not eligible for palliative surgeries.

Keywords: cannabinoids, nanoparticles, neurostimulation, peptides, pharmacoresistance, seizures

Similar articles



    1. Abbott, G. W. (2020). KCNQs: Ligand- and voltage-gated potassium channels. Frontiers in Physiology, 11, 583.
    1. Absalom, N. L., Ahring, P. K., Liao, V. W., Balle, T., Jiang, T., Anderson, L. L., Arnold, J. C., McGregor, I. S., Bowen, M. T., & Chebib, M. (2019). Functional genomics of epilepsy-associated mutations in the GABAA receptor subunits reveal that one mutation impairs function and two are catastrophic. Journal of Biological Chemistry, 294(15), 6157-6171.
    1. Adams, I. B., & Martin, B. R. (1996). Cannabis: Pharmacology and toxicology in animals and humans. Addiction, 91(11), 1585-1614.
    1. Alexander, S. P., Striessnig, J., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., Southan, C., Davies, J. A., & CGTP Collaborators. (2017). The concise guide to pharmacology 2017/18: Voltage-gated ion channels. British Journal of Pharmacology, 174(Suppl. 1), S160-S194.
    1. Allen, N. M., Weckhuysen, S., Gorman, K., King, M. D., & Lerche, H. (2020). Genetic potassium channel-associated epilepsies: Clinical review of the Kv family. European Journal of Paediatric Neurology, 24, 105-116.

Publication types

Leave a Reply

en English