Marijuana, lower urinary tract symptoms, and pain in the urologic patient.

PURPOSE:

To describe marijuana’s clinical role for urologic symptoms.

METHODS:

Studies related to marijuana, voiding dysfunction, lower urinary tract symptoms (LUTS), and pain through January 2019 from PubMed were evaluated for relevance and quality.

RESULTS:

Forty-eight studies were reviewed. Cannabinoids have mixed efficacy for neurogenic LUTS and little evidence for non-neurogenic LUTS, chronic non-cancer-related and perioperative pain. For cancer-related pain, high-level studies demonstrate cannabinoids are well-tolerated with unclear benefit.

CONCLUSIONS:

Cannabinoids appear well-tolerated in the short-term, but their efficacy and long-term impact is unproven and unknown in urologic discomfort. Cannabinoids for urologic symptoms should be further explored with well-designed RCTs.

Copyright © 2020. Published by Elsevier Inc.