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Canna~Fangled Abstracts

Neuromolecular Mechanisms of Cannabis Action

By December 17, 2020No Comments

doi: 10.1007/978-3-030-57369-0_2.

Affiliations 

Abstract

Most of our current understanding of the neuromolecular mechanisms of Cannabis action focusses on two plant cannabinoids, THC and CBD. THC acts primarily through presynaptic CB cannabinoid receptors to regulate neurotransmitter release in the brain, spinal cord and peripheral nerves. CBD action, on the other hand, is probably mediated through multiple molecular targets.

 

Keywords: cannabidiol, cannabinoid receptors, Δ9-Tetrahydrocannabinol

References

    1. Ahrens J, Leuwer M, Demir R, Krampfl K, de la Roche J, Foadi N, Karst M, Haeseler G (2009) Positive allosteric modulatory effects of ajulemic acid at strychnine-sensitive glycine alpha1- and alpha1beta-receptors. Naunyn Schmiedeberg’s Arch Pharmacol 379:371–378 – DOI
    1. Alharthi N, Christensen P, Hourani W, Ortori C, Barrett DA, Bennett AJ, Chapman V, Alexander SPH (2018) N-3 polyunsaturated N-acylethanolamines are CB2 cannabinoid receptor-preferring endocannabinoids. Biochim Biophys Acta Mol Cell Biol Lipids 1863:1433–1440 – PubMed – DOI
    1. Amada N, Yamasaki Y, Williams CM, Whalley BJ (2013) Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression. PeerJ 1:e214 – PubMed – PMC – DOI
    1. Andre CM, Hausman JF, Guerriero G (2016) Cannabis sativa: the Plant of the Thousand and one Molecules. Front Plant Sci 7:19 – PubMed – PMC – DOI
    1. Ashton JC, Glass M (2007) The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration. Curr Neuropharmacol 5:73–80 – PubMed – PMC – DOI

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