New cannabidiol derivatives: synthesis, binding to cannabinoid receptor, and evaluation of their antiinflammatory activity.
Abstract
- PMID:
16451075
[PubMed – indexed for MEDLINE]
Publication Types, MeSH Terms, Substances
Publication Types
MeSH Terms
- Animals
- Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis*
- Anti-Inflammatory Agents, Non-Steroidal/pharmacology
- Brain Stem/drug effects
- Brain Stem/metabolism
- Cannabidiol/analogs & derivatives*
- Cannabidiol/chemical synthesis*
- Cannabidiol/pharmacology
- Cell Line
- Macrophages/drug effects
- Macrophages/metabolism
- Male
- Mice
- Mice, Inbred BALB C
- Nitric Oxide/biosynthesis
- Radioligand Assay
- Rats
- Reactive Oxygen Species/metabolism
- Receptor, Cannabinoid, CB1/metabolism*
- Structure-Activity Relationship
- Synaptosomes/drug effects
- Synaptosomes/metabolism
- Tumor Necrosis Factor-alpha/biosynthesis
Substances
LinkOut – more resources
Full Text Sources
Other Literature Sources
Chemical Information
Molecular Biology Databases
Article
New Cannabidiol Derivatives: Synthesis, Binding to Cannabinoid Receptor, and Evaluation of Their Antiinflammatory Activity
Section:Abstract
Cannabidiol (CBD) and cannabidiol dimethyl hephtyl (CBD-DMH) were hydrogenated to give four different epimers. The new derivatives were evaluated for their ability to modulate the production of reactive oxygen intermediates (ROI), nitric oxide (NO), and tumor necrosis factor (TNF-α) by murine macrophages, and for their binding to the cannabinoid receptor (CB1). Surprisingly, we found that these derivatives exhibit good binding to CB1. In addition hydrogenated CBD and CBD-DMH demonstrate bioactivities different from their original compounds.
Citing Articles
View all 8 citing articles
Citation data is made available by participants in CrossRef’s Cited-by Linking service. For a more comprehensive list of citations to this article, users are encouraged to perform a search inSciFinder.
