For Your Consideration...

New Insights in Cannabinoid Receptor Structure and Signaling.

By February 14, 2019 No Comments
2019 Feb 14. doi: 10.2174/1874467212666190215112036.
[Epub ahead of print]

Abstract

BACKGROUND:

Cannabinoid has long been used for medicinal purposes. Cannabinoid signaling has been considered the therapeutic targets for treating pain, addiction, obesity, inflammation, and other diseases. Recent studies have suggested that in addition to CB1 and CB2, there are non-CB1 and non-CB2 cannabinoid-related orphan GPCRs including GPR18, GPR55, and GPR119. In addition, CB1 and CB2 display allosteric binding and biased signaling, revealing correlations between biased signaling and functional outcomes. Interestingly, new investigations have indicated that CB1 is functionally present within mitochondria of striated and heart muscles directly regulating intramitochondrial signaling and respiration.

CONCLUSION:

In this review, we summarize the recent progress in cannabinoid-related orphan GPCRs, CB1/CB2 structure, Gi/Gs coupling, allosteric ligands and biased signaling, and mitochondria-localized CB1, and discuss the future promise of this research.

KEYWORDS:

Allosteric ligand; Biased Signaling; Cannabinoid receptor; Mitochondria ; Orphan GPCRs; Structure

PMID: 30767756
DOI: 10.2174/1874467212666190215112036
en English