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Canna~Fangled Abstracts

Preclinical science regarding cannabinoids as analgesics: an overview.

By October 17, 2005No Comments
2005 Autumn;10 Suppl A:7A-14A.

pm8Preclinical science regarding cannabinoids as analgesics: an overview.


Modern pharmacology of cannabinoids began in 1964 with the isolation and partial synthesis of delta-9-tetrahydrocannabinol, the main psycho-active agent in herbal cannabis. Since then, potent antinociceptive and antihyperalgesic effects of cannabinoid agonists in animal models of acute and chronic pain; the presence of cannabinoid receptors in pain-processing areas of the brain, spinal cord and periphery; and evidence supporting endogenous modulation of pain systems by cannabinoids has provided support that cannabinoids exhibit significant potential as analgesics. The present article presents an overview of the preclinical science.




[PubMed – indexed for MEDLINE]