doi: 10.1016/j.biopha.2024.116445. Online ahead of print.
- PMID: 38503236
- DOI: 10.1016/j.biopha.2024.116445
Abstract
Dasatinib-related resistance frequently occurs and may lead to the failure of chemotherapy; thus, dose interruptions are necessary. Cannabidiol (CBD) has potential for integration with orthodox cancer care. In this study, we explored the combination effect of CBD and dasatinib on A549 cells. CBD in combination with dasatinib could induce significant synergistic apoptosis in vitro (ZIP > 10) and in vivo. The combination of CBD and low-dose dasatinib exhibited antiproliferative and proapoptotic effects through up-regulation of caspase-3 and Bax, and down-regulation of Bcl-2 in A549 cells. The xenograft mouse model suggested that the combination was more efficient and safer. In short, CBD and low-dose dasatinib exhibited a synergistic effect on anticancer by targeting the SRC/PI3K/AKT signaling pathway, suggesting a potential therapeutic option for the treatment of lung cancer.
Keywords: Apoptosis, Cannabidiol, Dasatinib, Lung cancer, SRC/PI3K/AKT pathway, Synergistic effect
Copyright © 2024. Published by Elsevier Masson SAS.
Conflict of interest statement
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors declare that they have no conflict of interest
Similar articles
-
Rapamycin Enhances the Anti-Cancer Effect of Dasatinib by Suppressing Src/PI3K/mTOR Pathway in NSCLC Cells.PLoS One. 2015 Jun 10;10(6):e0129663. doi: 10.1371/journal.pone.0129663. eCollection 2015.PMID: 26061184 Free PMC article.
-
Inhibition of SRC/FAK cue: A novel pathway for the synergistic effect of rosuvastatin on the anti-cancer effect of dasatinib in hepatocellular carcinoma.Life Sci. 2018 Nov 15;213:248-257. doi: 10.1016/j.lfs.2018.10.002. Epub 2018 Oct 5.PMID: 30292831
-
Target regulation of PI3K/Akt/mTOR pathway by cannabidiol in treatment of experimental multiple sclerosis.Fitoterapia. 2017 Jan;116:77-84. doi: 10.1016/j.fitote.2016.11.010. Epub 2016 Nov 25.PMID: 27890794
-
Cannabidiol alleviates hemorrhagic shock-induced neural apoptosis in rats by inducing autophagy through activation of the PI3K/AKT pathway.Fundam Clin Pharmacol. 2020 Dec;34(6):640-649. doi: 10.1111/fcp.12557. Epub 2020 Apr 13.PMID: 32215966
-
Activation of Focal Adhesion Kinase and Src Mediates Acquired Sorafenib Resistance in A549 Human Lung Adenocarcinoma Xenografts.J Pharmacol Exp Ther. 2017 Dec;363(3):428-443. doi: 10.1124/jpet.117.240507. Epub 2017 Oct 11.PMID: 29021381
LinkOut – more resources
-
Full Text Sources
-
Research Materials
-
Miscellaneous
