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Canna~Fangled Abstracts

The interaction between the endocannabinoid system and the renin angiotensin system and its potential implication for COVID-19 infection

By July 31, 2020February 2nd, 2021No Comments
 Since there are around 192 million people using cannabis worldwide, we believe that the mechanism underlying the hypotensive properties of cannabinoids should be urgently studied to understand if they can also lead to ACE-2 overexpression as other antihypertensive drugs do.
. 2020 Jul 31;2(1):23.

doi: 10.1186/s42238-020-00030-4.

Alberto Sainz-Cort 1, Joost H Heeroma 2
Affiliations 

Abstract

Background: Coronavirus disease 2019 (COVID-19) is spreading fast all around the world with more than fourteen millions of detected infected cases and more than 600.000 deaths by 20th July 2020. While scientist are working to find a vaccine, current epidemiological data shows that the most common comorbidities for patients with the worst prognosis, hypertension and diabetes, are often treated with angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs). BODY: Both ACE inhibitors and ARBs induce overexpression of the angiotensin converting enzyme 2 (ACE-2) receptor, which has been identified as the main receptor used by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter into the alveolar cells of the lungs. While cannabinoids are known to reduce hypertension, the studies testing the hypotensive effects of cannabinoids never addressed their effects on ACE-2 receptors. However, some studies have linked the endocannabinoid system (ECS) with the renin angiotensin system (RAS), including a cross-modulation between the cannabinoid receptor 1 (CB1) and angiotensin II levels.

Conclusion: Since there are around 192 million people using cannabis worldwide, we believe that the mechanism underlying the hypotensive properties of cannabinoids should be urgently studied to understand if they can also lead to ACE-2 overexpression as other antihypertensive drugs do.

 

Keywords: ACE-2, COVID-19, Cannabis, Endocannabinoid, Hypertension, SARS-CoV-2

References

    1. Cohen JB, Hanff TC, Bress AP, South AM. Relationship between ACE2 and other components of the renin-angiotensin system. Curr Hypertens Rep. 2020;22(7):44. – DOI
    1. COVID-19 situation update worldwide, as of 20 July 2020. European Centre for Disease Prevention and Control. Available from: https://www.ecdc.europa.eu/en/geographical-distribution-2019-ncov-cases . [cited 2020 Jul 20].
    1. Curfman G. Renin-angiotensin-aldosterone inhibitors and susceptibility to and severity of COVID-19. JAMA. 2020;324(2):177–8. – DOI
    1. Dinu AR, Rogobete AF, Bratu T, Popovici SE, Bedreag OH, Papurica M, et al. Cannabis sativa revisited-crosstalk between microRNA expression, inflammation, oxidative stress, and Endocannabinoid response system in critically ill patients with sepsis. Cells. 2020;28, 9(2):307.
    1. Emami A, Javanmardi F, Pirbonyeh N, Akbari A. Prevalence of underlying diseases in hospitalized patients with COVID-19: a systematic review and meta-analysis. Arch Acad Emerg Med. 2020;8(1):e35. – PubMed – PMC

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