Skip to main content
Canna~Fangled Abstracts

Therapeutic and Supportive Effects of Cannabinoids in Patients with Brain Tumors (CBD Oil and Cannabis)

By January 12, 2023No Comments

Review
. 2023 Jan 12.

doi: 10.1007/s11864-022-01047-y.

Online ahead of print.
J Eduardo Rodriguez-Almaraz 1 2, Nicholas Butowski 3 4
Affiliations 

Abstract

The potential medicinal properties of Cannabis continue to garner attention, especially in the brain tumor domain. This attention is centered on quality of life and symptom management; however, it is amplified by a significant lack of therapeutic choices for this specific patient population. While the literature on this matter is young, published and anecdotal evidence imply that cannabis could be useful in treating chemotherapy-induced nausea and vomiting, stimulating appetite, reducing pain, and managing seizures. It may also decrease inflammation and cancer cell proliferation and survival, resulting in a benefit in overall patient survival. Current literature poses the challenge that it does not provide standardized guidance on dosing for the above potential indications and cannabis use is dominated by recreational purposes. Furthermore, integrated and longitudinal studies are needed but these are a challenge due to arcane laws surrounding the legality of such substances. The increasing need for evidence-based arguments about potential harms and benefits of cannabis, not only in cancer patients but for other medical use and recreational purposes, is desperately needed.

Keywords: Antitumor therapy, Cannabinoids, Gliomas, Palliative care, Symptom management

Similar articles

See all similar articles

References

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
    1. von Bartheld CS, Bahney J, Herculano-Houzel S. The search for true numbers of neurons and glial cells in the human brain: a review of 150 years of cell counting. J Comp Neurol [Internet]. NIH Public Access; 2016 [cited 2022 Jun 17];524:3865. Available from: /pmc/articles/PMC5063692/
    1. Low JT, Ostrom QT, Cioffi G, Neff C, Waite KA, Kruchko C, et al. Primary brain and other central nervous system tumors in the United States (2014-2018): a summary of the CBTRUS statistical report for clinicians. [cited 2022 Mar 3]; Available from: https://academic.oup.com/nop/advance-article/doi/10.1093/nop/npac015/653…
    1. Patel AP, Fisher JL, Nichols E, Abd-Allah F, Abdela J, Abdelalim A, et al. Global, regional, and national burden of brain and other CNS cancer, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol [Internet]. Lancet Publishing Group; 2019 [cited 2022 Apr 9];18:376–93. Available from: http://www.thelancet.com/article/S147444221830468X/fulltext
    1. Ostrom QT, Cioffi G, Gittleman H, Patil N, Waite K, Kruchko C, et al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2012–2016. Neuro Oncol [Internet]. Oxford University Press; 2019 [cited 2022 Apr 15];21:v1. Available from: /pmc/articles/PMC6823730/
    1. Miller KD, Ostrom QT, Kruchko C, Patil N, Tihan T, Cioffi G, et al. Brain and other central nervous system tumor statistics, 2021. CA Cancer J Clin [Internet]. American Cancer Society; 2021 [cited 2022 Mar 27];71:381–406. Available from: https://onlinelibrary.wiley.com/doi/full/10.3322/caac.21693

Publication types

Leave a Reply