The cannabinoid receptor CB2 is highly expressed in immune cells suggesting its important role in numerous diseases like inflammation, cancer, osteoporosis or liver diseases in relation with modulation of the immune system. Thereby, activation of this receptor may be a hopeful therapeutic strategy to treat a large range of diseases. Indeed, selective CB2 agonists display beneficial anti-inflammatory, anti-cancer and antifibrogenic properties and positive effects on liver diseases and osteoporosis. This article will review the involvement of CB2 receptors in the immune system and the promising therapeutical potential of selective CB2 agonists in the treatment of several immune-related diseases.

PMID:

 24720538
[PubMed – as supplied by publisher]