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Canna~Fangled Abstracts

Unraveling the Mechanisms of Cannabidiol’s Pharmacological Actions: A Comprehensive Research Overview

By June 3, 2024June 11th, 2024No Comments

Review
. 2024 Jun 3;382(2):20.

doi: 10.1007/s41061-024-00465-w.

Iqra Kalsoom 1, Kiran Shehzadi 1, Han-Sheng Li 1, Hong-Liang Wen 1, Ming-Jia Yu 2
Affiliations 

Abstract

Cannabis sativa has long been used for neurological and psychological healing. Recently, cannabidiol (CBD) extracted from cannabis sativa has gained prominence in the medical field due to its non-psychotropic therapeutic effects on the central and peripheral nervous systems. CBD, also acting as a potent antioxidant, displays diverse clinical properties such as anticancer, antiinflammatory, antidepressant, antioxidant, antiemetic, anxiolytic, antiepileptic, and antipsychotic effects. In this review, we summarized the structural activity relationship of CBD with different receptors by both experimental and computational techniques and investigated the mechanism of interaction between related receptors and CBD. The discovery of structural activity relationship between CBD and target receptors would provide a direction to optimize the scaffold of CBD and its derivatives, which would give potential medical applications on CBD-based therapies in various illnesses.

Keywords: Cannabidiol, Cannabinoid receptor, Cannabis sativa, Mechanism, Structural activity relationship

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