Canna~Fangled Abstracts

Minnesota wild hemp: a crucial botanical source in early cannabinoid discovery

By September 11, 2020February 2nd, 2021No Comments
This research well prepared many junior chemists for prolific careers in both academia as well as industry, inspired the discoveries of later Cannabis investigators and also provided a successful model of a productive academic-government partnership
Review
. 2020 Sep 11;2(1):25.

doi: 10.1186/s42238-020-00031-3.

Crist N Filer 1 2
Affiliations 

Abstract

Renewed and sustained Cannabis chemistry exploration was initiated by Roger Adams at the University of Illinois Chemistry Department with cooperation from the Treasury Department Narcotics Laboratory in the early 1940’s. This partnership and time investment by both parties made practical sense. Adams was able to explore natural products chemistry and the Narcotics Laboratory began to clarify the chemistry mysteries of Cannabis. Minnesota wild hemp, often viewed as just a roadside weed, was employed as the critical botanical source. Based on its widespread cultivation during World War II, this was also a very pragmatic decision. Although the unique Illinois – Washington D. C. collaboration lasted only a few short years (1939-1942), the stunning results included the isolation and extensive characterization of cannabidiol, the structure elucidation and total synthesis of cannabinol as well as the identification of the tetrahydrocannabinol structure as an intoxicating pharmacophore. Furthermore, this research well prepared many junior chemists for prolific careers in both academia as well as industry, inspired the discoveries of later Cannabis investigators and also provided a successful model of a productive academic-government partnership.

 

Keywords: Cannabinoid, Federal Bureau of Narcotics, Minnesota wild hemp, Roger Adams, University of Illinois

References

    1. Adams R. Isolation of cannabidiol. US Patent. 1942;2,304,669.
    1. Adams R, Baker BR, Wearn RB. Structure of cannabinol. III. Synthesis of cannabinol, 1-hydroxy-3-n-amyl-6, 6, 9-trimethyl-6-dibenzopyran. J Am Chem Soc. 1940d;62:2204–7. – DOI
    1. Adams R, Harfenist M, Loewe S. New analogs of tetrahydrocannabinol. XIX J Am Chem Soc. 1949;71:1624–8. – DOI
    1. Adams R, Hunt M, Clark JH. Structure of cannabidiol, a product isolated from the marijuana extract of Minnesota wild hemp. I J Am Chem Soc. 1940f;62:196–200. – DOI
    1. Adams R, Loewe S, Pease DC, et al. Structure of cannabidiol. VIII. Position of the double bonds in cannabidiol. Marijuana activity of tetrahydrocannabinols. J Am Chem Soc. 1940a;62:2566–7. – DOI

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