Canna~Fangled Abstracts

The evaluation of Cannabidiol’s effect on the immunotherapy of Burkitt lymphoma.

By October 3, 2019 October 8th, 2019 No Comments
2019 Oct 3. pii: S0006-291X(19)31890-X. doi: 10.1016/j.bbrc.2019.10.001.
[Epub ahead of print]

Abstract

AIM:

AF1q has a precise oncogenic function. The purpose of this study is to investigate whether CBD has an effect on the AF1q/ICAM-1 regulatory axis in Burkitt’s lymphoma (BL), and thus has potential to enhance immunotherapy and reduce side effects.

METHODS:

We established BL cell lines with altered AF1q expression using lentivirus. After confirmation of gene expression by RT-PCR, cells were treated with CBD followed by co-culture of killing assay.

RESULTS:

AF1q increased oncogenic growth and colony formation, and induced resistance against cell-mediated cytotoxic chemotherapy through attenuation of ICAM-1 expression in BL. CBD was able to reverse the acquired resistance mediated by AF1q/ICAM-1 regulatory axis.

CONCLUSION:

CBD holds potential to enhance the efficacy of immunotherapy for BL with hyperactive AF1q/ICAM-1 regulatory axis, and warrants further study.

KEYWORDS: AF1q, BL, Burkitt lymphoma, CBD, Cannabidiol, ICAM-1, Immunotherapy

PMID: 31587870
DOI: 10.1016/j.bbrc.2019.10.001

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